從日本NHK報導探討梅子萃取物-MK615的功效

從日本NHK報導探討梅子萃取物-MK615的功效

 

有網友丟了一篇新聞報導,說『這就是梅精的人體實驗,證實對肝損傷有效』。

原報導網址:https://www.atpress.ne.jp/news/29574

 

其實,新聞報導並不能當作『佐證』,只是『新聞來源』。但因為內容真的很有興趣,報導也提及了真的有文獻報告:

這就很簡單搜尋了。

 

原始論文標題是:Efficacy of MK615 for the treatment of patients with liver disorders; World J Gastroenterol. 2012 Aug 21; 18(31): 4118–4126.  PMCID: PMC3422791

實驗中包含了動物和少量人體實驗。

提醒一下,因為原文內容很長,以下是為了便於非醫藥專業的網友理解,從一般民眾觀點,先抓幾個重點翻譯出來,並不是真正看論文的方式。

 

節錄翻譯

*AIM: To investigate the hepatoprotective effect of MK615, a Japanese apricot extract, in an animal model, and its clinical therapeutic effect.

目的:探討日本杏萃取物MK615在動物模型中的保肝臨床治療效果。.

 

*METHODS: Wistar rats were administered physiological saline (4 mL/kg) or MK615 solution (4 mL/kg) for 7 d. On the sixth d, acute hepatic injury was induced by administering a single intraperitoneal injection (ip) of D-galactosamine hydrochloride (D-GalN) (600 mg/kg). Plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined, and liver tissues were used for histopathological analysis. Fifty-eight patients with liver disorders [hepatitis C (n = 40), non-alcoholic fatty liver disease (n = 15), and autoimmune liver disease (n = 3)] were orally administered commercially available Misatol ME-containing MK615 (13 g/d) daily for 12 wk. Blood and urine were sampled immediately before and 6 wk, 12 wk, and 16 wk after the start of intake to measure various biochemical parameters. The percentage change in ALT and AST levels after 12 wk from the pre-intake baseline served as a primary endpoint.

58個有肝病的病人連續12周口服市售含有MK615的Misatol ME每天13公克。

 

*Japanese apricot (Prunus mume Sieb. et Zucc.), hereinafter referred to as ume, was brought to Japan from China around the eighth century.

Japanese apricot,底下簡稱ume(就是我們口語中的梅子或是青梅),是八世紀時從中國傳過去日本的。

 

*MK615, an extract from Japanese apricot, contains triterpenoids such as ursolic acid (UA)[2], oleanolic acid (OA)[2-4], lupeol[2,4], α-amyrin[2], and β-sitosterol[4].

MK615是一種日本杏的萃取物,包含有三萜類化合物如熊果酸、齊墩果酸、羽扇豆醇、α-香樹脂醇、β-谷甾醇。

 

*Preparation of MK615 solution: MK615 solution was prepared from a condensed extract of ume. In brief, ume were squeezed using a press, and the ume juice was then heated and concentrated 20-fold[5]. The condensed extract was neutralized using NaOH and was then heat-sterilized. The MK615 solution contained the neutral, condensed ume extract.

製備MK615溶液:MK615溶液是從濃縮的梅子萃取物而來。簡單說,用壓力把梅子擠壓,然後梅子汁加熱濃縮至20倍。然後濃縮液用氫氧化鈉中和再加熱消毒。MK615溶液包含了中性且濃縮的梅子萃取物(註:也就是說,MK615不是單純的梅精泡水而已)。

 

*DISCUSSION

This is the first study demonstrating that Misatol ME (a beverage containing MK615, an ume extract) lowers blood transaminase levels in patients with liver disorders such as chronic hepatitis C and NAFLD.

討論

這是第一個『顯示了Misatol ME(包含了MK615的一種飲品,梅子萃取物)降低了慢性C肝和非酒精性脂肪肝病人的血清轉胺酶』的研究。

 

*Because Misatol ME is a functional food, conducting the same controlled study to investigate its potential as a medicine was difficult. Nevertheless, the usefulness of Misatol ME as a functional food was clarified.

因為Misatol ME是一個功能性食品,進行同樣的對照研究變成為藥物是困難的。然而,Misatol ME很清楚可以作為一個機能性食品的用途。

 

*The mechanism underlying the hepatoprotective activity of Misatol ME in patients with chronic hepatitis C appears to involve the anti-inflammatory and antioxidative actions of the MK615 component of Misatol ME.

Misatol ME的肝臟保護機轉似乎是關於Misatol ME裡的MK615抗發炎及抗氧化能力。

 

*Peer review

The strongest point of this study should be the histological comparison of the rat livers with galactosamine-induced injury pretreated with MK615 and those not pretreated with MK615. The result is interesting and suggest that MK615 are promising hepatoprotective agents for patients with liver disorders.

同儕審查

結果是有趣,且建議在有肝臟疾病的病人身上,MK615是有希望的肝保護劑

 

討論

所以,整篇論文在討論『Misatol ME這個產品裡面的MK615這個三萜類化合物』,不是『梅精』這種東西。內容很侷限在 AdaBio株式会社的 Misatol ME 這個產品。

這樣是什麼意思?

  1. 這是AdaBio株式会社 旗下產品 Misatol ME 的研究結果。
  2. 結論是Misatol ME是個『有希望』的保肝劑保健食品。
  3. 研究對象是『有肝病的人』,不是一般人。
  4. Misatol ME的研究結果,不能比照去其他的梅子萃取物。若廠商想要有這類結論,必須自己產品仿照整個實驗內容去跑流程看看。

 

所以,若是有廠商拿 AdaBio株式会社 的 Misatol ME 研究結果,尤其人家是在說一個產品的萃取物成份MK615,卻拿來當作自家梅精產品的背書,那就是拿明朝的劍斬清朝的官,完全沒有道理,風馬牛不相干了!

文獻,是這樣看的,不是看標題,大聲就贏。

至於這文獻有沒有版權?

例如這一篇,刊載在US National Library of Medicine(美國國立醫學圖書館)裡面且公開閱覽的,一般使用,絕對沒有問題。

當然,假如有人拿去商業用途,或許就是另外一回事了。

 

結論

說『這就是梅精的人體實驗,證實對肝損傷有效』是對一半錯一半的,原因如上面所說:

  1. 這是 AdaBio株式会社 的 Misatol ME  的研究結果,不是『一般梅精』。
  2. 實驗對象只有58人,只是小型研究,所以結論是可以當保健品用,不能替代一般治療。

 

網路上很多這類真假摻半的醫藥資訊,若沒有專業的人來過濾,很多網友就容易被方向牽著跑,或是被網路流傳影片的聳動的言詞所誘導,甚至聽過『像我隨便找吼』這類台詞,就是我們最怕的,因為隨便找,也沒有看一下內容,甚至不懂內容能不能拿上檯面就拿來說詞,就是容易會誤導民眾。

我們『健康說真話』,對於每一份文獻,都是很謹慎地看待,絕對不會『隨便找』就隨便拿出來說明,這才是『專業』的態度。

 

記得一個原則:『食品,不能訴求療效』,或許如實驗有相關好處,但結果肯定因人而異,千萬不能期待太多。而假如有廠商對自家產品有信心,就請『遵照法規』,去申請健康食品字號,就能夠提及療效,也不用幾乎每個月都被衛生局罰一次了。

 

當然,假如網友對於該實驗內容有興趣,應該找的是AdaBio株式会社 的 Misatol ME  ,不是一般廠商的梅精了。原因就如上面我們討論的,應該能理解。

http://shop.adabio.co.jp/shopdetail/001000000001/

 

*假如您有「藥品的副作用」「健康食品的禁忌症」和「健康食品與藥品彼此的交互作用」此三類問題,歡迎您透過Line來諮詢True Health專業藥師,True Health也會透過Line與您分享健康新知識喔!

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